FEMA No. 2239
Cellulose CM
CAS: 9000-11-7;177317-30-5;191616-54-3;196886-89-2;204336-41-4
Molecular Formula: C6H12O6
FEMA No. 2239 - Names and Identifiers
FEMA No. 2239 - Physico-chemical Properties
| Molecular Formula | C6H12O6 |
| Molar Mass | 180.15588 |
| Density | 1.050 g/cm3(Temp: 15-18 °C) |
| Boling Point | 527.1°C at 760 mmHg |
| Flash Point | 286.7°C |
| Solubility | Practically insoluble in anhydrous ethanol. It swells with water to form a suspension and becomes viscid in 1 M sodium hydroxide. |
| Vapor Presure | 2.59E-13mmHg at 25°C |
| Appearance | White or yellow solid |
| Storage Condition | Room Temprature |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
FEMA No. 2239 - Risk and Safety
| WGK Germany | 1 |
| RTECS | FJ5700000 |
| HS Code | 3912310000 |
| Toxicity | LD50 unreported in mammal (species unspecified): 13340mg/kg |
FEMA No. 2239 - Reference
| Reference Show more | 1. Wang Jian. Study on intestinal absorption and prevention of thrombosis and material basis of two color coreopsis extract in rats [D]. Xinjiang Medical University 2016. 2. Wang Ting, Zhang Xiaoxia, Li Yiwei, Yue Jiang, Dongtian, hongyanweng, Xin, Liu Ping, Dong Youping, Wang Hao. Protective effects of flaxseed oil on insulin resistance and oxidative stress in rats with polycystic ovary syndrome [J]. Modern Food Science and Technology 2020 36(07):17-24. 3. Zhang Donghui, Dong Xiang, Ma Na, et al. Effects of curcumin on vital signs and related blood indexes of heatstroke rats in dry and hot desert environment [J]. Laboratory Animal Science, 2017, 34(001):7-10. 4. Zhang Donghui, Song Laiyang, Liu Jiangwei, et al. Effects of curcumin on neutrophils in blood and tissues of heat stroke rats in dry and hot desert environment [J]. Chinese Journal of Comparative Medicine, 2019, 029(006):80-85. 5. Li Asia, Shao Yanhao, Tang Huanhuan, et al. Protective effect of curcumin combined with Erzhi pill on immune hepatitis induced by concanavalin A in mice [J]. Shi Zhen, National Medicine, 2020, 3 (4):769-773. 6. Zhang Donghui, Xue Xiaoyu, Xie Zhi, et al. Effects of curcumin pretreatment on histological and ultrastructural changes of skeletal muscle in rats in dry heat environment [J]. Laboratory Animal Science, 2018, v.35(03):5-10. 7. Ma Na, Li Jiajia, Zhou Jing, et al. Protective effect of curcumin pretreatment on myocardium of rats with heat stroke in dry heat environment. 8. Yang Hao, former Li, Xu Jing. Development of wheat germ beverage [J]. Agricultural products processing, 2020, No.496(02):7-10. 9. He Meizhi, Yang Luwei, Zhang Zhentao. Supercooling characteristics of inorganic phase change material CaCl_2 · 6H_2O [J]. Journal of Chemical Engineering, 2017,68(11):4016-4024. 10. Tan Ruixin, Zhang Wangang, Zhou Guanghong. Preparation and antioxidant and antibacterial properties of oregano essential oil-carboxymethyl cellulose active packaging film [J]. Science and Technology of food industry, 2019(12). 11. Wang Shengnan, Miao Xin, Dong Zhiqiang, etc. Study on Toxicokinetic/Toxicokinetic model of cardiotoxicity induced by radix aconiti multiflori [J]. Pharmacology and Clinic of Traditional Chinese Medicine, Volume 36, No. 3, 2020, pages 12-130, microscopic PKU CSCD, 2020. 12. Lin Ling, Liu Zhi-jun, Lei Zheng-yan, et al. Effects of tea seed saponins on intestinal flora in hyperlipidemia rats [J]. Natural product research and development, 2020(2). 13. Lin Ling, Liu Zhi Jun, Zeng Wen Zhi, Lei Zheng Yan, Lin Quan female, Cheng Fujian, Yang Jiang Fan. Effect of tea seed saponin on regulating blood lipid in hyperlipidemia rats [J]. Science and Technology of food industry, 2020,41(07):278-283. 14. Chen loulu, Zhong Xiaolan, Zhu, Yingmin, et al. Establishment and evaluation of adjuvant-induced arthritis model in female Lewis rats. 15. Gu Liyuan, Sheng Yujun, Li Zhiyao, etc. Pharmacological study of huangkui capsule on experimental colitis induced by TNBS in mice [J]. Journal of Yangzhou University: Agriculture and Life Science, 2020, 29 (1):27-32. 16. Zhang Qiongqiong, Wei Jia, Zhang Jian, etc. Effects of hydrogen sulfide fumigation on cell wall and diseases of postharvest seedless grapes [J]. Science and Technology of food industry, 2020(13). 17. Yu Han, Zhong Xianggen, Li Yunzhou, Xu zonying, Shi Shaohua, Deng Xiulan. Effects of melatonin on NO, MDA, GSH and NADPH in rats with intrahepatic cholestasis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019,24(11):1221-1226. 18. Yang Gang, Yang diqin, Cao Wentao, Wang Xiaodan. Optimization of cellulose-degrading bacteria and degradation process of distiller's grains [J]. Journal of Agricultural Engineering, 2020,36(13): 21-221. 19. Feng Lunyuan, He Lanping, Li Cuiqin, et al. Screening of microbial β-glucosidase for hydrolyzing ginkgo flavone glycosides from traditional fermented soybean products in Guizhou [J]. Journal of Microbiology, 2020(2). 20. Xie Weijie, Zhang Yongping, Xu Jian. Screening Matrix formulation of indomethacin hydrophilic gel patch by uniform design [J]. China Pharmacy, 2017(10). 21. Wang Runnan, Zhao Dandan, gold, Hao Jianxiong, Han Xue, Hu gaoshuang, Rao Huan, Guan Junfeng. Enhanced drying characteristics and quality improvement of apple slices by coating-ultrasonic composite pretreatment [J]. Modern food science and technology, 2020,36(10):226-235 132. 22. Peng Jing, Chen Xi. Protective effects of scoparone on acute liver injury induced by carbon tetrachloride in mice [J]. China Pharmacy, 2021,32(02):231-235. 23. Liu G. Study on quality evaluation of Panax notoginseng from different habitats [D]. Beijing University of Chinese Medicine, 2020. 24. Gong Qinqin, Wang Qian, Guo Ling, Xu Jian, Zhang Yongping. Preparation and quality evaluation of celastrol oral ulcer film [J]. China Pharmacy, 2020,31(21):2574-2578. 25. Tingting, Chen Jiashu, Huang Guiying, Xin Yanping, Zeng Xiaofang, Chen Haiguang, Ye shaohuan, Zhang Yung, Feng Weihua, Huang Dexian. Effect of ozone on quality and antioxidant activity of preserved orange peel [J]. Modern food science and technology, 2020,36(09):109-116 25. 26. Mengyuan Zhang. Study on solid state fermentation of soybean meal and its protein emulsification characteristics [D]. Hubei University of Technology, 2020. 27. See in the water, Li Yueming, Li Dan, zynina, Zhang zonsen, Xu Jianchun, Xu binzheng. Study on the preparation technology of egg yolk wine [J]. Journal of fermentation science and technology, 2021,50(01):50-52 62. 28. Shen Rui-ling, Li Jia-Yao, Zhu Yingying, Dong Jilin. Study on whole-grain micro-fermentation drink of oat [J]. Food Research and Development, 2021,42(02):78-83. 29. Zhu, J., et al. "Effect of Na2CO3 on the Microstructure and Macroscopic Properties and Mechanism Analysis of PVA." CMC Composite Film, Polymers 12.2 (2020). 30. Feng, Shuxuan, et al. "Maskless patterning of biodegradable conductors by selective laser sintering of microparticle inks and its application in flexible transient electronics." ACS applied materials & interfaces 11.49 (2019): 45844-45852.https://doi.org/1 31. [IF=8.198] Yawen Cai et al."Rational Synthesis of Novel Phosphorylated Chitosan-Carboxymethyl Cellulose Composite for Highly Effective Decontamination of U(VI)."Acs Sustain Chem Eng. 2019;7(5):5393-5403 32. [IF=4.22] Wei Qinghua et al."Research on the miscibility, mechanical properties and printability of polylactic acid/poly (ε-caprolactone) blends: insights from molecular dynamics simulation and experiments."J Mater Sci. 2021 Jun;56(16):9754-9768 33. [IF=5.537] Zhen Li et al."Combined effects of 1-methylcyclopropene and tea polyphenols coating treatment on the postharvest senescence and reactive oxygen species metabolism of bracken (Pteridium aquilinum var. latiusculum)."Postharvest Biol Tec. 2022 Mar;185:111813 |
FEMA No. 2239 - Nature
Open Data Verified Data
- carboxymethyl cellulose is the most representative ionic cellulose ether, and its sodium salt is commonly used, so it is also called sodium carboxymethyl cellulose. In addition, its ammonium salt, aluminum salt, and the like may also be present.
- pure CMC is a white or yellowish fibrous powder or granular solid, odorless and tasteless. CMC is easily dispersed in water to form a colloidal solution with a certain viscosity. The equilibrium moisture of CMC increases with the increase of air humidity and decreases with the increase of temperature. At room temperature and an average humidity of 80% ~ 85%, the equilibrium moisture is above 26%, and the moisture in the product is about 10%, which is lower than the equilibrium moisture. The viscosity of CMC solution is related to concentration, temperature, pH value, storage time and salts. Carboxymethyl in CMC can react with polyvalent metal ions; Can react with iodic acid, nitrogen dioxide, chlorite, hydrogen peroxide and other chlorinating agents and ultraviolet rays, in the presence of alkali, the oxidation reaction causes the main chain to break, which causes the degree of polymerization to decrease, that is, the viscosity decreases; In the presence of acid catalyst, it is easy to hydrolyze, so the main chain breaks, and the degree of polymerization decreases; CMC can be used with alkali metal, amines can form salts, monovalent salts are soluble, the most common such as sodium salts, more than divalent salts such as zinc, barium, aluminum, copper becomes insoluble. Although CMC solution is more difficult to corrupt than natural gum, but under certain conditions, especially the role of cellulase, amylase will cause its corruption, resulting in a decrease in viscosity. The digestive enzymes in the human body do not have the decomposition effect on CMC, which is the reason why CMC can be used in the food industry
Last Update：2025-06-10 22:55:16
FEMA No. 2239 - Preparation Method
Open Data Verified Data
In the process of manufacturing CMC, the main chemical reactions are: (1) alkaline reaction of cellulose and alkali aqueous solution to produce alkali cellulose; (2) alkali cellulose and sodium chloroacetate (or monochloroacetic acid) an etherification reaction occurs. The production method of CMC can be divided into two types: a water-based method using water as a reaction medium and a solvent-based method using an organic solvent as a medium.
- the water-based method is the most classic method in the production of CMC, and is still used by some factories. Characterized by simple equipment, low investment, low cost, can manufacture low-grade CMC products, used in detergents, textile sizing, adhesives and oil industry and other fields.
- solvent method is characterized by short production cycle, high product quality, wide application range, but high material consumption, high equipment investment, high cost.
Last Update：2022-01-01 11:08:23
FEMA No. 2239 - Application
Open Data Verified Data
- used in synthetic detergent and soap industry, CMC has the effect of emulsifying and protective colloid, and is the best active agent for synthetic detergent. The amount of CMC added to the general detergent is 0.5% ~ 2.0%, and it is determined that the addition of 2%CMC detergent can keep the whiteness of white fabric above 90% after washing.
- used in oil and gas drilling, well excavation and other projects, the addition of CMC in the mud can form thin and hard, low permeability filter cake, so that the water loss is reduced, so as to reduce the mud without water, infiltration into the formation caused by the shrinkage, collapse, drop and other phenomena.
- used in textile, printing and dyeing industry as cotton, wool, silk, chemical fiber and other fabrics warp sizing, not only can save a lot of food and edible oil, but also has good stability, high yarn quality, smooth, wear-resistant and other effects; As a printing paste can also improve the color of the printing, the dyed fabric is soft, and the effect is more mottled and non-mildew.
- application in the paper industry as a smoothing agent, acid agent in the paper industry. When 0. 1%~ 0. 3% CMC is added to the pulp, the paper tension can be increased by 40% ~ so%, and the paper is uniform, which is convenient for the infiltration of printing ink.
- used in the silicate industry can be used as a blank adhesive, plasticizer, fixing agent, etc., in the concrete construction to add CMC can reduce water loss, play a retarding effect, improve building strength and service life.
- used in food industry, CMC is odorless, tasteless, non-toxic, easy to dissolve, can be stored for a long time without corruption, high viscosity, strong shape retention, so it is widely used in the food industry, for example, as a thickener for jam, a stabilizer for ice cream, a molding agent for jelly, a surface coating preservative for vegetables and fruits, and the like.
- emulsion stabilizers for various injections in the pharmaceutical industry, base materials for ointments, adhesives for tablets, etc.
- It is used as a molding agent for daily industrial products such as toothpaste, a stabilizer for skin cream, an adhesive for mosquito coil, etc. In addition, it is also used for leather polishing agent, colorant, foam fire extinguishing agent stabilizer, pesticide dispersant, coating industry gluing agent, formaldehyde production and storage of polymerization inhibitor, film and Photographic film surface treatment agent. Toxicity and protection this product is non-toxic and non-hazardous.
Last Update：2025-08-19 16:24:40
FEMA No. 2239 - Safety
Open Data Verified Data
sodium carboxymethyl cellulose must be used in kraft paper three-in-one composite bag, lined with polyethylene film bag. Net quality 25kg per bag, or according to user requirements packaging. Because CMC is very easy to absorb water, it should be prevented from sun and rain during transportation. Storage should be placed in a clean, dry, ventilated warehouse, to prevent direct sunlight, away from heat sources, not mixed with toxic substances, mixed transport.
Last Update：2025-06-10 22:55:16
FEMA No. 2239 - Molding Process
Open Data Verified Data
most of the water-soluble properties, processing into a gum-like thickener, emulsifier, dispersant, oil drilling mud and fabric sizing agent, treatment agents and ceramic adhesives.
Last Update：2025-06-10 22:55:16
FEMA No. 2239 - Reference Information
| FEMA | 2239 | CARBOXYMETHYLCELLULOSE |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | carboxymethyl cellulose (CMC) is a kind of tackifier, which is a non-toxic and tasteless white flocculent powder at room temperature, stable performance, soluble in water, its aqueous solution is neutral or alkaline transparent viscous liquid, soluble in other water-soluble glue and resin, insoluble in organic solvents such as ethanol. Carboxymethyl cellulose is a carboxymethyl group substitution product of cellulose. Depending on their molecular weight or degree of substitution, they may be fully soluble or insoluble polymers which act as weak acid type cation exchangers for the separation of neutral or basic proteins, etc. |
| Application | carboxymethyl cellulose can form high viscosity colloid, solution, adhesion, thickening, flow, Emulsion dispersion, water retention, protective colloid, film forming, acid resistance, salt tolerance, suspension and other characteristics, and physiological harmless, so in food, medicine, daily chemical, petroleum, paper, textile, construction and other fields have been widely used in production. Its main uses: cigarette bonding, fabric sizing, shoe paste meal, household paste. The inner wall of the building is sprayed, and the imitation porcelain is made, the mortar is thickened and the concrete is enhanced. Molding bonding for the production of refractory fibers and ceramics. Thickening and reduction of water loss of mud for oil drilling and site exploration. High quality paper surface sizing. Soap and Detergent detergent additives, as well as other industrial production of dispersion, emulsification, stability, suspension, film formation, paper making, polishing agents and so on. Among them, high quality products can also be used in toothpaste, medicine, food and other industrial sectors. |
| storage | carboxymethyl cellulose should be stored in a cool and dry place at a temperature below 40°C and a relative humidity below 75%. Under the above conditions, it can be stored for 24 months from the date of production. |
| Use | CMC soluble in water can significantly increase the viscosity of the solution, with thickening, dispersion, emulsification, suspension, protective colloid and other effects, and physiological harmless, in food, medicine, daily chemical, petroleum, paper, textile, construction and other fields of production has been widely used. gel type: cellulose gel, ion exchange type. Structural components: highly cross-linked cellulose. Particle size: 50um. Ligand: carboxymethyl. 70mg nuclease/ml. The particle type hydrophilic polymer with an average particle size of 50 μm is used, and the surface is linked with macromolecular sugar, so that it has a higher specific surface area and better biocompatibility, and maintains a higher load under high water flow, at the same time, it has better resolution for the separation of biological polymers. |
Last Update：2024-04-10 22:41:03
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